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In this study, all methods were performed in accordance with the relevant guidelines and regulations

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(Wan et al., 2016) found that the system could restore the NP phenotype following dedifferentiation through upregulating NP-specific genes ( KRT-8, KRT-18, FOXF-1 ) and the SAPH stimulated time-dependent increases in aggrecan and type II collagen deposition (Figure 7)

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In addition, the dual GLP-1 receptor/glucagon receptor agonist, the dual GLP-1 receptor/GIP receptor agonist or the triple GLP-1 receptor/GIP receptor/glucagon receptor agonist may each be a conjugate (particularly a protein or peptide) comprising any of the GLP-1 receptor agonists described herein covalently attached, optionally via a linker, to a glucagon receptor agonist and/or to a GIP receptor agonist

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