aod9604 phase 2 trial results weight loss kg or percent Stalled on Ozempic Mounjaro? What the evidence on AOD-9604 as an adjunct actually says AOD-9604 Vial — Lyophilized, HPLC

Composition 5-amino-1MQ: 5 mg Appearance: lyophilized powder in a sealed research vial Research Focus (non-clinical) Investigation of NNMT inhibition and its downstream metabolic effects Studies on NAD+ metabolism and energy homeostasis in preclinical models Development of analytical methods for small-molecule quantitation Stability and solubility assessment of 5-amino-1MQ under laboratory storage conditions Documentation Lot-specific COA available Batch and lot traceability Important Notice For research use only Not for human consumption Not intended to diagnose, treat, cure, or prevent any disease Quality & Manufacturing Lot-specific COA Lyophilized for transit stability

10.1007/s11606-021-06751-3 7 CamperiJ.CombesA.GuibourdencheJ.GuillarmeD.PichonV.FournierT.et al (2018)

Multiple studies show significant body weight reduction and improved body composition

Too little produces minimal effect

AOD is a reconstructed form of the amino acids 176-191 and is a synthetic lipolytic domain, meaning it serves as a synthetic alternative for the natural growth hormone produced by your body

the desired C2/3-diamino-group may be introduced via a two-step sequence involving an amination of C2-chloro- group with, for example, ammonia and reduction of C3-nitro group (via, e.g., hydrogenation) to give the precursor 16