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aureus bshA mutant

Through TULP1 knockout models in zebrafish, scientists found that TULP1 deficiency causes early-onset retinal degeneration through up-regulating ferroptosis-related genes, increasing the shrinkage of mitochondria, iron and lipid droplet deposition and reducing mitochondria cristae, and increasing the death of photoreceptors via ferroptosis (Jia et al., 2022)

Statistical analysis involved propensity score matching, weighted means and percentages, t-tests, chi-square tests, multivariate logistic and linear regression using SAS 9.4 software

Accessed February 12, 2025

The sample size included 478 AD (female: 318, male: 160) and 300 control (female: 148, male: 152) cases on which sex-stratified meta-analysis (Wan et al., 2020)

Notably, the modulation of iron metabolism regulatory elements like TfR1, DMT1, and transferrin protein 1 can potentially sway the onset and intensity of ferroptosis