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Fatigue is common and can be caused by many things, including: Iron deficiency Low vitamin D Thyroid issues Poor sleep quality or sleep apnoea Stress and burnout Low mood/anxiety Dietary patterns and hydration Long-term conditions Thats why we always recommend basing B12 treatment on clinical context, and ideally blood test results, rather than guessing

We and others have recently shown that the distribution of intrinsic disorder propensity within the amino acid sequence of mature IGF-1 is markedly different compared to E-domains 5,13

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