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Because the brain lacks large triglyceride storage and retains only small glycogen reserves, it relies on a constant input of blood-borne metabolites ( Glucose is the brain's principal fuel and a necessary precursor for the synthesis of lipids, proteins, and neurotransmitters like acetylcholine, glutamate, and gamma-aminobutyric acid (GABA)

Next, we detected the levels of DCFH-DA and found that, compared to control cells, the ROS levels were significantly higher in ACTL6A-KD cells with or without H 2 O 2 treatment (Fig