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However, concerns remain regarding potential harm to humans from specific compounds that have shown hazardous effects in laboratory animals

A human neutralizing antibody targets the receptor-binding site of SARS-CoV-2

This argument is perhaps a bit of a moot point in the current COVID-19 environment, but this argument also fails when one recognizes that restaurants and entertainment industries did not cease to exist in those countries that moved to BAC 0.05%

Many preclinical studies conclusively shown that berberine plays a therapeutic role in many central nervous system disorders such as Alzheimer s disease, cerebral ischemia, depression, schizophrenia, epilepsy, and anxiety (Fan et al., 2017