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Copper binds to and inhibits protein tyrosine phosphatase N2 (PTPN2), leading to the loss of its phosphatase activity

This approach allows for the calculation of mitochondrial respiration parameters illustrated in Figure 1bg, including basal respi- ration, ATP production, maximal respiration and spare respiratory capacity

10.1128/CMR.00125-18 [DOI] [PMC free article] [PubMed] [Google Scholar] Ascenzi P, Bettinelli M, Boffi A, Botta M, De Simone G, Luchinat C, Marengo E, Mei H, & Aime S (2020)

Increase in NAD but not ATP and GTP concentrations in rat liver by dehydroepiandrosterone feeding

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Sci Adv 7 (1):eabc7409 Ngo V, Duennwald ML (2022) Nrf2 and oxidative stress: a general overview of mechanisms and implications in human disease