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Navarro VJ, Seeff LB

Xc- system and GPX4 Inhibition of xCT protein or GPX4 leads to ferroptosis, which provides a possible therapeutic target for the treatment of septic myocardial injury (Fig

For example, deletion or pharmacological inhibition of NAMPT promotes a very sharp decline in muscle, but a more modest reduction in the liver [37,38,84]

These TCMs share common features: potent toxicity, a narrow therapeutic window, and strong therapeutic actions that readily impair spleen and stomach function

Sample preparation may include centrifugation, filtration, precipitation, or desalting and buffer exchange

Subsequently, cells were stained with 10 L Annexin V-FITC and 5 L PI (Beyotime) for 15 min in the dark, followed by immediate flow cytometric analysis