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Ciclopirox (CPX), initially an FDA-approved antifungal agent, has shown significant effects against ferroptosis and suppresses non-small cell lung cancer (NSCLC) growth through iron chelation (Lin et al., 2021

2021), although most studies describing a decrease in GPx activity come from work done with MASLD animal models

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Further studies identified the dependence of ROS-induced apoptosis on the persistent activation of pro-apoptotic mitogen-activated protein kinase (MAPK) pathways (cJun N-terminal kinases [JNKs] and p38), which modulated the phosphorylation of mitochondrial pro-apoptotic and anti-apoptotic proteins [26, 27]

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Another way in which glutathione improves muscle performance is by promoting muscle protein synthesis