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Both medications have potential long-term risks, such as hormonal imbalances with Sermorelin and gastrointestinal or cardiovascular issues with Semaglutide

Many Nrf2 inducers including electrophilic agents such as dimethyl fumarate and natural products like sulforaphane, act on multiple cellular targets beyond Keap1, raising the possibility of off-target effects such as immunomodulation, altered drug metabolism or unintended transcription changes [130]