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In a late-onset familial AD (FAD) mouse model, H3K9 dimethylation (H3K9me2) and histone methyltransferase 1 (EHMT1) and EHMT2 were significantly increased in the prefrontal cortex, a key cognitive region in AD (Zheng et al., 2019)

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Gordon-Blake J, Ratia K, Weidig V, Velma GR, Ackerman-Berrier M, Penton C, et al

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Considering this and the evolutionary divergence of Nematoda, we hypothesise that diversification of CAT within metazoans is relatively recent compared to the long evolutionarily history of this enzyme

102 It has a novel mode of action that is distinct from that of other tubulin inhibitors: it terminates microtubule elongation to trigger cell death with no effect on microtubule depolymerization