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Activation of the Reverse Transsulfuration Pathway Through NRF2/CBS Confers Erastin-Induced Ferroptosis Resistance

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Moreover, the hydrogel provided anchoring sites for liposomes that further reduced the degradation rate

The rate constants from our deglutathionylation assays between 6.4 10 4 and 1.4 10 6 M 1 s 1 are very similar to the rate constants for PfGrx or plant and mammalian glutaredoxins from discontinuous or coupled enzymatic assays with other high and low molecular weight GSSR substrates (Table 1) 9,11,14,19 , thus confirming our assay as an alternative reliable method for the direct analysis of enzyme-catalyzed deglutathionylations

Clinically, such events are often linked to pronounced immune activation, extensive pulmonary inflammation, and prolonged immune dysregulation, and may be more likely to present with severe respiratory manifestations, including respiratory failure