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(ii) In eukaryotes, 3-hydroxy-3-methylglutaryl-CoA synthase 2 (HMG synthase 2) catalyzes the condensation of acetoacetyl-CoA with a third acetyl-CoA to form HMG-CoA (Bahnson, 1960

Altogether, by enabling the TCA cycle, Fe-S clusters take part in the controlled combustion of nutrients and supply metabolic precursors for nucleotide, lipid, and protein biogenesis

Monocle2 pseudotime analysis further confirmed that, relative to natural aging, the additional effect of HHcy caused endothelial cells to diverge in different directions and accelerated their transition from pre-aging to senescence, as evidenced by the bifurcation at Branch Point 1 (Figure 2K)

"The long- and short-term impact of elevated body mass index on the risk of new atrial fibrillation the WHS (women's health study)." J Am Coll Cardiol 55 (2010): 2319-2327

It is also vital for energy production and cognitive function

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