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Very rarely, more serious reactions can occur, such as a severe allergic reaction

Unfortunately, I cant answer that question for you since there are so many variables to take into consideration

Since, the calculated K-value is a function of Reynolds Number and nominal pipe diameter, the K-value is applicable for various pipe sizes, pipe materials, fluids and fluid velocities

It has to be mentioned that KO mice for IGF-1 gene are not viable and studies in such mice have to be done in the first days of life, and thus results are not very conclusive as metabolism is not properly established at this stage [129, 228]