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OTA causes acute depletion of striatal dopamine and its metabolites, accompanying evidence of neural cell apoptosis in the substantia nigra, stratum and hippocampus [68]

10.1210/en.2006-0815

Hardan, A.Y., Fung, L.K., Libove, R.A., Obukhanych, T.V., Nair, S., Herzenberg, L.A., Frazier, T.W., and Tirouvanziam, R., Biological Psychiatry , 2012, vol

Using covalent immobilization of small peptide residues, you can typically obtain a better orientation of the molecule and reduced problems with antibody recognition of the peptide due to masking of the epitope

The peptide consists of just 15 amino acids with a tyrosine modification at the N-terminus, creating a stable fragment that selectively targets adipose tissue