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IR and IGF-1R display approximately 50% sequence homology (Ullrich et al., 1986)

Once at the IGF-1 receptor it triggers the same downstream anabolic cascade as IGF-1 PI3K/Akt and MAPK signaling that promotes protein synthesis and satellite-cell activity but its poor binding-protein affinity also means rapid clearance [3]

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This study shows that IGF1 has efficacy in type 1 diabetes

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