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ROS can induce the stabilization of HIF-1, which in turn upregulates VEGF expression, promoting the formation of new blood vessels to supply the growing tumor with nutrients and oxygen [115]

Many genes have both strengths and weaknesses, and understanding both sides of a gene can help remove any fear and the notion that not all genotypes are inherently better than another

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Accordingly, the increased iron reliance can be regarded as a promising target for treating GBM by inducing ferroptosis

However, the result does not show a significant correlation with the SOFA score