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Therefore, especially when surgical management involves amputation, an initial incisional biopsy is essential to confirm the clinical diagnosis of melanoma.Acral-lentiginous melanomas should be managed with special attention, as these clinical features are usually associated with poorer outcome

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This melanin-increasing function is its most notorious, but the drug has several otherpotentially dangerouseffects and has been reported to cause heart, blood, and eye disorders, among other conditions

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