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Along with serving as biosynthetic substrates, the G6PD-mediated metabolitesRu-5-P and NADPH regulate downstream signaling cascades and induce tumorigenesis (Lin et al., 2015)

Kabiljo J, Laengle J, Bergmann M

Ultimately, after being released into the synaptic space, it is taken up by surrounding neurons and glia, resulting in neurodegeneration (Lee et al., 2010