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They bind to specific receptors on cell surfaces, triggering downstream signaling cascades that regulate everything from growth and metabolism to immune responses and neurological function

It turns out that there are a large number of people (anywhere from 20 to 40% (3)) who have small genetic mutations which impact how well this process works

PMID: 3603115

My only gripe is with the dual applicator

On enterocytes and monocytes, gliadin binds to the CXCR3 chemokine receptor, which provides a signal for the cell to increase zonulin synthesis