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Mutations in the SFTPC gene, which codes for surfactant protein C, have been identified in individuals with familial interstitial lung disease and emphysema

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10.1016/j.arr.2020.101038 55 DorlingJ

A 2024 phase II clinical trial found that although the 12-month DFP treatment successfully reduced the iron content in the hippocampus, it accelerated the cognitive decline of the patients, suggesting that reducing brain iron in such patients may be harmful (143)

Subsequent analysis using the UK Biobank dataset not only confirmed this finding but also revealed an association between the causal SNP in the GPR146 locus, rs1997243, and C-reactive protein (CRP) levels, as well as plasma liver enzymes, including gamma glutamyl-transferase (GGT), aspartate transaminase (AST), and alkaline phosphatase (ALP) 16,17

Alkaloids are organic compounds with a cyclic ring structure containing one or more basic nitrogen atoms [15] and are often used to treat infectious diseases [16] and antiviral agents [17]