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H., van der Poel, A

Sex- and stage-related sensitivity of Schistosoma mansoni to in vivo and in vitro praziquantel treatment

Fibroblasts secrete inflammatory cytokines and chemokines, such as tumor necrosis factor-alpha (TNF-), IL-1, and chemokine (C-X-C Motif) ligand 8 (CXCL8), contributing to the inflammatory environment

PROTACs frequently fail to accumulate effectively in target tissues or subcellular compartments, while off-target deposition in organs such as the liver or adipose tissue may potentiate toxicity [10]