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Hence, the validation of the physiological relevance of the detected interactions remains a major challenge

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The infection leads to the imbalance between oxidant and antioxidant defense mechanisms through inhibiting the antioxidant activity as well as the inability to neutralize the impact of ROS released [25, 78, 79]

Although this approach has promising results in infection neutralization, large-scale creation of monoclonal antibodies is costly, labor intensive, and time-consuming, especially against emerging pathogens

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Therapeutic Implications: Restoring the Glutathione-Mitochondrial-Vascular Axis Understanding glutathione as a central integrator of redox, mitochondrial, and vascular signaling provides a clear rationale for interventions designed to restore homeostasis and cardiometabolic resilience