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T.BothaG.RamsayM.MasimirembwaC.et al (2021)

One explanation for the extremely low systemic presence of IL-1 is that ELISA assays primarily measure free IL-1

A single injection also carries less risk of side-effects, such as stomach irritation, than many oral anti-inflammatory medications

They represent a carefully identified sequence from a larger protein called Body Protection Compound, which the human stomach produces naturally as part of its protective mechanisms

Taken together, the data suggest that strong T-cell responses can be found in patients with a broad range of clinical presentations, whereas strong antibody titres are more closely linked to severe COVID-19