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The most recognizable physical signs of high cortisol include: Weight gain around the abdomen and lower back that does not respond to diet or exercise A rounded, puffy face, sometimes called cortisol face Thinning skin that bruises easily Slow wound healing High blood sugar or worsening insulin resistance High blood pressure Frequent infections from a suppressed immune system These physical changes happen because cortisol in excess breaks down muscle tissue for fuel, promotes fat storage in the midsection and keeps blood sugar chronically elevated

doi: 10.3390/pharmaceutics17010119

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The study confirmed that FOXO4-DRI disrupts FOXO4-p53 binding in endothelial cells, facilitating phosphorylated p53 nuclear exclusion and triggering the BAX/caspase-3 apoptotic cascade specifically in senescent endothelial cells

Insulin signaling misregulation underlies circadian and cognitive deficits in a Drosophila fragile X model

Blood Transfus 18:290294 van de Donk NWOH, El Haddad O et al (2016) Interference of daratumumab in monitoring multiple myeloma patients using serum immunofixation electrophoresis can be abrogated using the daratumumab IFE reflex assay (DIRA)