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These adaptations are regulated by hypoxia-inducible factor-1 (HIF-1), which controls various biological pathways

Nat Med (2001) 7:5417.10.1038/87865 101 SchmiderJLammersCHGotthardtUDettlingMHolsboerFHeuserIJ

Emotional factors, such as anxiety, depression, or emotional trauma, can affect menstrual cycles through their influence on stress hormones and the central nervous system, says Dr Lee