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In the two approved albumin fusions, GLP-1 and FIX are fused to the N-terminal end of albumin due to functional requirements of the biologics 66,67,88,89,90,91

When astrocytes undergo glycolysis, glucose is quickly converted into L-lactate, which is then transported out of the cells through monocarboxylate transporters (MCTs)specifically MCT1 and MCT4 on astrocytes and MCT2 on neurons

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Egawa H, Ueda Y, Kawagishi N, Yagi T, Kimura H, Ichida T

Cuproptosis induced by ROS responsive nanoparticles with elesclomol and copper combined with PD-L1 for enhanced cancer immunotherapy

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