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151 Observational evidence suggests people with tinnitus have higher levels of markers of oxidative stress than those without tinnitus

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Laboratory studies have demonstrated: Increased collagen synthesis Upregulation of COL1A1 and COL3A1 gene expression in fibroblast cultures Enhanced glycosaminoglycan production Increased decorin and versican expression MMP modulation Balanced regulation of matrix metalloproteinase activity Reduced matrix degradation Decreased expression of matrix-degrading enzymes Antioxidant Signaling GHK-Cu exhibits antioxidant properties through multiple mechanisms: Gene Expression Modulation Microarray studies have shown that GHK-Cu influences the expression of hundreds of genes

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