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Hippocampal CA1 betaCaMKII mediates neuroinflammatory responses via COX-2/PGE2 signaling pathways in depression

If hepatic failure develops, acetylcysteine should be continued beyond the standard doses until hepatic function improves or until the patient has a liver transplant

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Response: We clarify that practitioners participating in the ACO REACH Model, the Making Care Primary model, and the Primary Care First model would satisfy the proposed initiating visit, patient population-level management, and performance measurement APCM service elements and practice-level capabilities by virtue of meeting requirements of their model participation, and that we are not waiving any of the APCM service elements or requirements for practitioners in these models or the Shared Savings Program