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Ikari et al., 2013

KEY FINDINGS To start, we analysed publically available sequencing data of cancer patient samples and found that the expression of serine and glycine synthesis enzymes was significantly increased in T-cell leukaemia patient samples that present NKX2-1 overexpression (Figure 2)

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Abbreviations NMN: (nicotinamide mononucleotide) ALD: (Alcoholic liver disease) NAD + : (Nicotinamide adenine dinucleotide) SIRT1: (Sirtuin 1) NMNAT: (Nicotinamide mononucleotide adenylyl transferase) NAMPT: (Nicotinamide Phosphoribosyltransferase) CYP2E1: (Cytochrome P-450 2E1) ALT: (Alanine aminotransferase) AST: (Aspartate aminotransferase) TC: (Cholesterol) TG: (Triglyceride) MDA: (Malondialdehyde) SOD: (Superoxide dismutase) GSH: (Glutathione) PCR: (Polymerase Chain Reaction) WB: (Western Blotting ) ELISA: (Enzyme-Linked Immunosorbent Assay) HE: (Hematoxylin-eosin) TNF-: (Tumor necrosis factor-) IL-6: (Interleukin-6) IL-1: (Interleukin-1) ROS: (Reactive oxygen species) GAPDH: (Glyceraldehyde-3-phosphate dehydrogenase) ATP: (Adenosine Triphosphate) ADP: (Adenosine Diphosphate) ZO-1: (Zonula Occludens-1 Protein) PMSF: (Phenylmethylsulfonyl fluoride) RIPA: (Radio immunoprecipitation assay) SDS: (Sodium dodecyl sulfate) TEMED: (Tetramethylethylenediamine) TBST: (Tris-Buffered Saline with Tween-20) PVDF: (Polyvinylidene fluoride) TBS: (Tris Buffered Saline) SDS-PAGE: (Sodium dodecyl sulfate - polyacrylamide gelelectrophoresis) References Lim SS, Vos T, Flaxman AD et al

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Metformin reduces the rate of small intestinal glucose absorption in type 2 diabetes