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In a model of human rheumatoid arthritis fibroblasts (HFLS-RA) induced by TNF- and a rat model of rheumatoid arthritis established by type II collagen injection, catalpol decreases the production levels of IL-6, MCP-1, and IL-1 by weakening the signaling activity of YAP/transcriptional co-activator with PDZ-binding motif (TAZ)

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Branded GLP-1 and GIP obesity drugs carry approximate US list prices on the order of US$1,000 to US$1,400 per month before insurance or savings programs (2026