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The presurgical visit occurred approximately 1 month before the DBS surgery, whereas the post-surgical visits occurred at 1, 3, 6 and 12 months after surgery

Oxalate crystals can accumulate in the joints, skin, vasculature, and even the brain leading to inflammation, mitochondrial dysfunction, and cell damage

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In selected experiments, changes in the intracellular Fe pool were independently validated via the use of a BioTracker 575 Red Fe Dye (Merck), a highly specific fluorescent sensor that increases in signal intensity upon binding to Fe