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Cash A, Kaufman DL

QD community oral or SC MOTS-c Daily SC, often 5 days on / 2 off AOD-9604 Daily SC Attribute Max studied dose SLU-PP-332 50 mg/kg BID (mouse, 28 days) MOTS-c 5-15 mg/kg (mouse) AOD-9604 1-5 mg/day in human Phase 2 Attribute Peak efficacy signal SLU-PP-332 ~25-30% fat-mass reduction in DIO mice over 28 days MOTS-c Improved insulin sensitivity in aged mice AOD-9604 Modest fat-loss signal in human Phase 2

Santoro A, Vileno B, Palacios et al (2019) Reactivity of Cu(II), Zn(II) and Fe(II)thiosemicarbazone complexes with glutathione and metallothionein: from stability to dissociation to transmetallation

Step 4: Follow up with your doctor Depending on which medications you are taking, youll have follow-up lab tests (typically every 90 days) and review the results with your doctor

Nature 489 , 220230 (2012)

Also, of note fully 50% of the 1mg group dropped out of the trial and not because of side effects