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Leibowitz, J., Kaufman, G

Inconsistent sleep patterns can disrupt the liver's ability to manufacture antioxidants

However, due to the compensatory mechanisms that appear when any specific target is inhibited, the clinical effect of improving drug resistance is not very significant

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FAD is important for producing energy both from carbohydrates and through fatty-acid oxidation in the mitochondria.[ref] FAD is also involved in detoxification as a cofactor for some CYP450 enzymes, as well as for glutathione recycling

The 3 more important isomers are silybin (or silibinin), silydianin, and silychristin, being the former the most active of these compounds [573]