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Ethanol metabolism, CYP2E1 induction, compromised antioxidant defenses, mitochondrial injury, activation of Kupffer and stellate cells, hypoxia, and iron overload can all contribute to the alcohol-induced oxidative environment

The dissociated modified tau protein becomes more sensitive to phosphorylation, making it more prone to hyperphosphorylation, misfolding, and abnormal aggregation (Zhang X

Psychiatry 32, 886890

VPS35 regulates mitochondrial fusion protein 2 (Mfn2) by controlling the transport of mitochondrial ubiquitin ligase 1 (MUL1) to the mitochondrial membrane, promoting mitochondrial fusion, which in turn increases ATP production and reduces mitophagy [105]