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Conversely, microbial dysbiosis defined as alterations in richness and relative abundances of the gut is implicated in the pathogenesis of several chronic neurological and neurodegenerative disorders

Furthermore, intestinal crypts cultured with elesclomol or PF9366 formed significantly fewer intestinal organoids (Fig

doi: 10.1038/s41573-020-00135-8 Cardoso, Fernanda C., Castro, Joel, Grundy, Luke, Schober, Gudrun, Garcia-Caraballo, Sonia, Zhao, Tianjiao, Herzig, Volker, King, Glenn F., Brierley, Stuart M

The collision of replication forks with immobilised topoisomerase 1, which can be trapped on the DNA by camptothecin (CPT), triggers the phosphorylation of the DNA damage checkpoint kinase Chk1 at serine 345 by Rad3 26