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The tryptophan residue at position 3 has been identified as particularly important for receptor engagement through hydrophobic interactions with the KISS1R binding pocket

Further studies have established that APR-246 can also trigger p53-independent cell death in several solid cancers, suggesting that besides p53, other cellular targets might be involved in APR-246 effect [56]

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Hopefully, similar studies in well-characterized cohorts might ultimately enlighten the role of glutathione-related genetic variants in Hg toxicity (e.g., via meta-analysis)

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In contrast, health hazards associated with long-term environmental exposure to low concentrations of lead have been reported steadily