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Interference with epithelial barrier integrity (e.g., by pathogenic microbes or drugs) leads to enhanced gut permeability and enables translocation of previously confined (and potentially harmful) microorganisms into the tissue and to distal locations including secondary lymph nodes and liver, where they trigger inflammatory responses 2,3,4

Janus kinase/signal transducer and activator of transcription signaling Another mechanism for GH resistance in uremia is a defect in post-receptor GH-activated Janus kinase/signal transducer and activator of transcription (JAK/STAT) signaling (Fig

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doi: 10.1016/j.cell.2015.05.025 101 OberkampfMGuillereyCMourisJRosenbaumPFayolleCBobardAet al