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ClinicalTrials.gov identifier: NCT03625648

Notably, multiple APP and Tau models exhibit NPS-related deficits, suggesting that these behavioral changes may not be tied to specific pathologies but rather to some shared factors such as alterations in neuronal activity or synaptic functions

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Defects in the gene encoding ubiquitin carboxy-terminal hydrolase 1 (UCH-L1) cause familial PD, PARK5

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Another study among older adults who engaged in several types of exercise, including running, racquet sports, walking, golf, swimming, and cycling, found that all forms of exercise reduced all-cause, cardiovascular, and cancer mortality, compared to those who did not participate in these activities (see Sidebar 11 ) (174)Watts EL, et al