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The cell-surface transmembrane E3 ubiquitin ligases Zinc and Ring Finger 3 (ZNRF3) and Ring Finger Protein 43 (RNF43) act as negative feedback regulators of Wnt/-catenin signaling by inducing the degradation of FZD and LRP6 in a DVL-dependent manner, and R-spondin (RSPO) ligand binding to leucine-rich repeat-containing G protein-coupled receptor (LGR) 4/5 receptors can clear ZNRF3 and RNF43 to strengthen Wnt/-catenin signaling

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Ferroptosis suppressing protein 1 (FSP1) protects cells from ferroptosis by acting as a redox enzyme that consumes NADH/NADPH to reduce coenzyme Q 10 (CoQ 10 )

Strain survival rate (%) = [E/C] 100%, E is the number of colonies in the experimental group, C is the number of colonies in the control group

To analyze the role of mitochondria in atorvastatin-induced ferroptosis, mitochondrial content of Fe 2+ , ROS and lipid peroxidation were detected

It helps make red blood cells, preventing anemia