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Selective antitumor activity and photocytotoxicity of glutathione-activated Abasic Site Trapping agents

As the upstream RLuc reporter is translated by cap-dependent scanning 58 , which is reported to be enhanced in YBX1 deficiency 59 , to compare the translational efficiency of the PRKAA1 5UTR in shCtrl and shGDH1 or shYBX1 cells, the FLuc activity of the empty reporter group was used for normalization, as previously described 38

FEBS Lett 2011, 585: 37703780

Abbreviations PH: partial hepatectomy GST: glutathione S- transferase GSH: glutathione TRAF2: tumor necrosis factor receptor-associated factor 2 ASK1: apoptosis signal regulating kinase 1 MAPK: mitogen-activated protein kinase JNK: c-jun N-terminal kinase ERK: extracellular signal regulated kinase MCM: minichromosome maintenance ROS: reactive oxygen species BrdU: 5-bromo-2'-deoxyuridine ATF: activating transcription factor CDK: cyclin-dependent kinase ALT: alanine aminotransferase AST: aspartate aminotransferase References Fausto N, Campbell JS, Riehle KJ

Bouyahya A, Chamkhi I, Balahbib A, Rebezov M, Shariati MA, Wilairatana P, Mubarak MS, Benali T, El Omari N (2022) Mechanisms, anti-quorum-sensing actions, and clinical trials of medicinal plant bioactive compounds against bacteria: a comprehensive review

Clinical safety data from phase II trials for inflammatory bowel disease show BPC-157 exhibited particular wound healing effects with no reported toxicity