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GPX4 plays a pivotal role in regulating lipid peroxides within cells and the reduction in GSH and GPX4 that we demonstrate in the IB3-1 AECs following FAC and erastin treatment is likely responsible for the increased lipid peroxidation that we found, as evidenced by the increase in MDA and C11-BODIPY

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May JM, Morrow JD, Burk RF

Pdx1Cre), its variants, and their application in immunooncology drug discovery

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