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This partnership becomes more important as we age because both nutrients become less available

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Furthermore, we validate that S -nitrosylation of the trihelix transcription factor GT-1 by S -nitrosoglutathione promotes its binding to NO-responsive elements in the HsfA2 promoter and that loss of function of GT-1 disrupts the activation of HsfA2 and heat tolerance, revealing that GT-1 is the long-sought mediator linking signal perception to the activation of cellular heat responses

Moreover, Gladkova et al

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So, characterizing the transcriptome of GBM has yielded profound insights into the highly variable transcriptomic features of GBM and its microenvironmental cell components