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doi: 10.1002/aur.2617 57 LeiterO.ZhuoZ.RustR.WasielewskaJ

These in vitro results have been further validated in murine models of malaria infection and rheumatoid arthritis, where G6PD-d or inhibition leads to less severe proinflammatory responses to stimulation marked by reduced Th1 and Th17 differentiation, decreased proatherogenic cytokines IL-1, IL-6, IL-12, and TNF, and no impact on IL-10 and TGF (classically Treg-derived) 120,121,122,123,124

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In addition to innate immune cells, CD8+ T cells can be found surrounding the acinar or ductal epithelial cells (58), while CD4+ T cells are mainly located within the ductal epithelial cells (58), and B cells can also infiltrate the ductal epithelial cells (59)

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