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It mediates nitric oxides biological effects in cellular signaling and acts as a redox-dependent modulator of physiological functions [71]

Environ Res 220:115133 Roh H, Kim A, Kim N, Lee Y, Kim D (2020) Multi-omics analysis provides novel insight into immuno-physiological pathways and development of thermal resistance in rainbow trout exposed to acute thermal stress

While fatty acid oxidation produces more ATP per gram, it requires more oxygen and can be slower than glucose oxidation in producing ATP, which increases risks such as hypoxia and oxidative stress to the cell [119]

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In contrast, FOXO4-DRI treatment significantly reduced the cell number in the PDL9 group (Supplementary Figures 1, 2)

Standard research protocols follow a 4-week-on, 4-week-off pattern to allow receptor density restoration