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Since the binding affinity of natural glycopeptides is not sufficient to stimulate the proliferation and differentiation of primitive B cells into plasma cells that secrete antibodies--which leads to the immune system's self-tolerance, synthetic glycopeptide vaccines are the best option

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The recombinant N-terminal domain of spike proteins is a potential vaccine against Middle East respiratory syndrome coronavirus (MERS-CoV) infection

He Y, Cheng X, Zhou T, Li D, Peng J, Xu Y, et al