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Moreover, EPA and DHA can also reduce the serum total cholesterol (STC) contents of serum total cholesterol and corticosterone (a glucocorticoid), and induce 5-HT and NE deficiency in the hippocampus, suggesting that EPA and DHA exert antidepressant activity by regulating HPA (Peng et al., 2020)

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By activating glucagon signaling in the liver, Retatrutide increases resting metabolic rate and mobilizes hepatic lipid stores, contributing to both weight loss and improvements in metabolic dysfunction-associated steatotic liver disease (MASLD) (Sanyal et al., 2024

1.3 Pathogenesis and molecular mechanisms Immunological interaction, genetic factors and environmental variables are important in etiology of PsO