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First-line therapy for neuropathic pain includes gabapentinoids, tricyclic antidepressants (TCAs), and serotoninnorepinephrine reuptake inhibitors (SNRI) and second-line medications include opioids and topical treatments such as capsaicin [51]

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Even mild TBI, often dismissed as "just a concussion," initiates these secondary processes at a reduced but still significant scale