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AMPK activation during energy deficiency can both inhibit ferroptosis, through phosphorylation of ACACA/ACC (acetyl-CoA carboxylase alpha) in MEFs (mouse embryonic fibroblasts) and human renal adenocarcinoma cells [68], and promote ferroptosis, by targeting BECN1 (beclin1)-mediated system xc - inhibition in human colorectal cancer cells [25] or regulating pyrimidinosome assembly in human cervical cancer cells [69]

Bernal PJ, Leelavanichkul K, Bauer E, Cao R, Wilson A, Wasserloos KJ, et al

10.1515/tjb-2024-0031 238 SunM.SuX.DingB.HeX.LiuX.YuA.et al (2012)

2025 Nov 19;13(11):e012652

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