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Selenium deficiency as a possible factor in the pathogenesis of myxoedematous endemic cretinism

Although, cells physiologically produce a certain amount of ROS (e.g.: respiratory chain in mitochondria), excessive production has the potential to significantly damage cell homeostasis, mainly through oxidative modifications of DNA/RNA and proteins

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The pairwise sequence alignments show the CSD site has been undergoing rapid evolution since its introduction in both clades (Figure S2)